Wilentin — Trientine 250 mg (100 Capsules)
Wilentin 250 mg (Trientine) is a vital medication belonging to the group of chelating agents. The active substance — trientine hydrochloride — is specifically designed to remove excess copper from the body. The drug is the primary alternative treatment for patients who cannot tolerate penicillamine due to severe side effects.
Manufacturer: Inpharmus, Turkey. Wilentin works by forming stable complexes with copper in the blood and tissues, which are then safely excreted by the kidneys. This helps prevent toxic damage to the liver, brain, and other vital organs characteristic of copper metabolism disorders.
Key Features:
- ✅ Effective Chelation Therapy: High ability to bind free copper and reduce its accumulation in tissues.
- ✅ Improved Tolerability: Has fewer serious side effects compared to first-generation drugs (penicillamine).
- ✅ High Quality Standard: The drug is produced by Inpharmus in accordance with strict pharmaceutical protocols.
Wilentin 250 mg is prescribed by geneticists, hepatologists, and neurologists for:
- 🔹 Wilson's Disease: Treatment of a hereditary disorder involving copper accumulation in the body in patients intolerant to penicillamine.
- 🔹 Maintenance Therapy: Long-term control of copper levels in the body to prevent recurrence of liver and central nervous system damage symptoms.
Sales Form: 1 pack contains 100 hard capsules of 250 mg.
⚠️ INSTRUCTIONS FOR USE:
- Administration: Take strictly on an empty stomach — at least 1 hour before meals or 2 hours after meals.
- Dosage: The dose is selected individually based on copper levels in urine and blood serum. Usually, the daily dose is divided into 2–4 intakes.
- Method: The capsule should be swallowed whole with water only. Do not chew or open the capsule.
- Interactions: Do not take simultaneously with iron supplements or antacids. There should be an interval of at least 2 hours between their intake.
- Storage: Store in a tightly closed container in the refrigerator (at 2°C–8°C). Brief exposure to room temperature is acceptable, but overheating should be avoided.
- ⛔ Allergic Reactions: Hypersensitivity to trientine or any of the inactive components of the drug.
- ⛔ Pregnancy and Lactation: Used only in cases where the expected benefit to the mother outweighs the risk to the fetus. Strict medical supervision is required.
- ⛔ Special Instructions: Patients with systemic lupus erythematosus require extremely careful monitoring.
The following side effects may occur when using Wilentin and require medical attention:
- 🩸 Iron Deficiency: Trientine can bind iron, which sometimes leads to the development of anemia (short-term iron supplementation may be required, but separately from Wilentin).
- 🤢 Digestion: Heartburn, abdominal pain, nausea, sometimes diarrhea.
- 🧴 Skin Reactions: Skin rash, itching.
- 🧠 Neurology: In rare cases, a temporary worsening of neurological symptoms (dystonia, tremor) may occur at the beginning of therapy.
- ⚠️ Important: During trientine treatment, regular tests are necessary to monitor bone marrow function and blood ferritin levels.
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