Denopsy 14 — Teriflunomide 14 mg (30 Tablets)
Denopsy 14 (Teriflunomide) is a modern immunomodulatory drug designed for the disease-modifying treatment of multiple sclerosis. Teriflunomide is a selective inhibitor of the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH), which plays a key role in pyrimidine synthesis. Through this mechanism, the drug selectively limits the proliferation of hyperactive lymphocytes (T and B cells) responsible for inflammation and nerve fiber damage in multiple sclerosis.
Manufacturer: Natco Pharma, India. Denopsy 14 effectively reduces the frequency of exacerbations (relapses) and slows the progression of physical disability. The drug features a convenient dosing form and a good safety profile, making it a preferred choice for long-term maintenance therapy.
Key Features:
- ✅ Disease Control: Significant reduction in the risk of developing new brain lesions visible on MRI.
- ✅ Convenient Regimen: Oral administration once a day eliminates the need for frequent injections, improving treatment compliance.
- ✅ Selectivity: The drug targets active lymphocytes while preserving the overall protective function of the immune system.
Denopsy 14 is prescribed by neurologists for the following indications:
- 🔹 Relapsing-Remitting Multiple Sclerosis (RRMS): Treatment of adult patients to reduce the frequency of clinical relapses and slow the accumulation of physical disability.
- 🔹 Clinically Isolated Syndrome (CIS): The first manifestation of a demyelinating disease that has a high risk of progressing to clinically definite multiple sclerosis.
Sales Form: 1 pack contains 30 tablets of 14 mg (3 blisters of 10 tablets).
⚠️ INSTRUCTIONS FOR USE:
- Dosage Regimen: The recommended dose is 14 mg (1 tablet) once daily.
- Administration: The tablet should be swallowed whole with water. It can be taken with or without food.
- Monitoring: Before starting therapy and during treatment, it is necessary to regularly monitor liver enzyme levels (ALT/AST) and blood pressure.
- Storage: Store at temperatures not exceeding 30°C in a dry place, protected from sunlight.
- ⛔ Pregnancy and Family Planning: Teriflunomide has teratogenic effects. It is categorically contraindicated in pregnant women. Women of childbearing age must use reliable contraception. Men should also consider the risk when planning fatherhood.
- ⛔ Liver Diseases: Severe hepatic impairment (Child-Pugh Class C).
- ⛔ Immunodeficiencies: Severe immunodeficiency states (e.g., AIDS).
- ⛔ Blood Disorders: Significant anemia, leukopenia, or thrombocytopenia.
- ⛔ Infections: Severe active infectious diseases until they are cured.
- ⛔ Lactation: Use during breastfeeding is contraindicated.
The drug may cause side effects that require monitoring by a specialist:
- 💇♀️ Hair: Hair thinning or mild alopecia (usually temporary and resolves within a few months).
- 🤢 GI Tract: Nausea, diarrhea, abdominal pain.
- 🧪 Liver: Increased levels of liver transaminases (ALT).
- 🤒 General: Headache, upper respiratory tract infections (nasopharyngitis), flu-like symptoms.
- 🩸 Blood: A slight decrease in white blood cell count.
- ⚠️ Important: If signs of liver damage appear (jaundice, dark urine, pain in the upper right abdomen), consult a doctor immediately.
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