Palbocent 125 Capsules — Palbociclib 125 mg (21 Capsules) Incepta
Palbocent 125 mg (Palbociclib) is an advanced targeted anticancer therapy and a first-in-class selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). Its mechanism of action focuses on blocking the cell cycle in the G1 phase, thereby preventing the division and growth of malignant cells in hormone-sensitive tumors. Palbocent significantly delays disease progression when administered in conjunction with endocrine therapy.
Manufacturer: Incepta Pharmaceuticals Ltd. This medicinal product is a high-quality generic of the innovator drug Ibrance. It is manufactured under strict quality control standards, ensuring full bioequivalence and identical therapeutic efficacy to the brand-name medication.
Key Features:
- ✅ Selective Inhibition: Specifically targets CDK4/6 proteins, which are key drivers of cancer cell proliferation.
- ✅ Endocrine Synergy: Potentiates the efficacy of aromatase inhibitors and fulvestrant.
- ✅ Clinical Evidence: Proven to significantly extend progression-free survival in patients with metastatic breast cancer.
Palbocent is indicated for the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer:
- 🔹 In combination with an aromatase inhibitor as initial endocrine-based therapy in postmenopausal women.
- 🔹 In combination with fulvestrant in women with disease progression following prior endocrine therapy.
Sales Unit: 1 pack containing 21 capsules, each containing 125 mg of Palbociclib.
⚠️ APPLICATION INSTRUCTIONS:
- Dosage: The standard dose is 125 mg (one capsule) taken orally once daily for 21 consecutive days, followed by 7 days off treatment (a 28-day cycle).
- Method: Swallow capsules whole. Must be taken with food to ensure optimal absorption and consistent plasma levels.
- Consistency: Take the dose at approximately the same time each day.
- Storage: Store in the original package at a temperature below 30°C in a dry place.
- ⛔ Pregnancy and Breastfeeding: Known to cause fetal harm. Strictly contraindicated during pregnancy and nursing.
- ⛔ Organ Impairment: Severe hepatic or renal dysfunction.
- Hypersensitivity to Palbociclib or any of its excipients.
- Pediatric use (safety and efficacy in children under 18 have not been established).
Professional medical monitoring, including regular blood counts, is required. Potential side effects include:
- 🩸 Hematologic: Neutropenia (very common), leukopenia, anemia, and thrombocytopenia.
- 🏃♂️ General: Fatigue (asthenia) and physical weakness.
- 🤢 Gastrointestinal: Nausea, stomatitis, vomiting, and diarrhea.
- 🦠 Infections: Increased risk of infections due to low white blood cell counts.
- 💅 Dermatologic: Alopecia (hair thinning) and skin rash.
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