Valgahet Tablets — Valganciclovir 450 mg (60 Tablets) Heet
Valgahet 450 mg (Valganciclovir) is a potent antiviral drug designed for the treatment and prevention of cytomegalovirus (CMV) infection. Valganciclovir is a precursor of ganciclovir: after oral administration, it is rapidly converted into its active form by hepatic and intestinal enzymes. The drug effectively blocks the synthesis of viral DNA, stopping the reproduction of the virus in the body.
Manufacturer: Heet Health Care. Valgahet is a high-quality generic of the original drug Valcyte. Due to its excellent oral bioavailability, it achieves concentrations of the active substance in the blood comparable to intravenous administration of ganciclovir, making treatment more comfortable for the patient.
Key Features:
- ✅ High Bioavailability: Effectively absorbed in the gastrointestinal tract, providing reliable virus control without the need for constant injections.
- ✅ Golden Standard: The primary agent for preventing CMV infection after organ transplantation.
- ✅ Convenient Packaging: The bottle contains 60 tablets, which is optimal for long-term induction or maintenance therapy courses.
Valgahet is prescribed by an infectious disease specialist or a transplant surgeon in the following cases:
- 🔹 CMV Retinitis: Treatment of cytomegalovirus retinitis (damage to the retina) in patients with AIDS.
- 🔹 Post-Transplant Prevention: Prevention of CMV disease in patients after solid organ transplantation (kidney, heart, pancreas) who are at risk.
Sales Form: 1 bottle containing 60 tablets of 450 mg valganciclovir.
⚠️ INSTRUCTIONS FOR USE:
- Dosage Regimen: For active treatment (induction), the usual dose is 900 mg (2 tablets) twice daily for 21 days. For prevention or maintenance therapy — 900 mg (2 tablets) once daily.
- Method of Administration: Tablets should be taken orally with food. This significantly improves the absorption of the drug.
- Important: Tablets must not be broken or crushed. Since valganciclovir has potential teratogenic and carcinogenic effects, avoid skin or mucosal contact with the powder from damaged tablets.
- Renal Function: Patients with impaired renal function require mandatory dose adjustment by a physician.
- ⛔ Pregnancy and Lactation: The drug has pronounced teratogenic effects. Categorically contraindicated for pregnant women. Men and women must use reliable methods of contraception during and for 90 days after treatment.
- ⛔ Blood Counts: Treatment should not be started if the level of neutrophils (less than 500/µl), platelets (less than 25,000/µl), or hemoglobin (below 80 g/l) is critically low.
- ⛔ Pediatric Use: Contraindicated for children under a certain age/weight (except for specific post-transplant prevention protocols in children).
- Hypersensitivity to valganciclovir, ganciclovir, or acyclovir.
Taking Valgahet requires regular monitoring of blood counts. Possible effects:
- 🧪 Hematology (most common): Neutropenia (low white blood cells), anemia, thrombocytopenia. Regular complete blood counts are necessary.
- 🤢 GI Tract: Diarrhea, nausea, vomiting, abdominal pain.
- 🌡️ General: Fever, chills, increased fatigue.
- 🧠 Neurology: Headache, insomnia, in rare cases — tremors or confusion.
- 🍄 Infections: Risk of secondary infections (e.g., oral candidiasis) due to suppressed immunity.
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