6-MP Tablets — Mercaptopurine 50 mg (100 Tabs) Zydus
6-MP 50 mg (Mercaptopurine) is a vital antineoplastic medication belonging to the group of antimetabolites (purine analogues). Its mechanism involves interfering with the synthesis of DNA and RNA in rapidly dividing cells, which leads to the destruction of malignant cells. It is a cornerstone of maintenance therapy in leukemia protocols.
Manufacturer: Zydus Lifesciences (India). 🇮🇳 One of India’s leading pharmaceutical corporations, recognized for high manufacturing standards and compliance with international IP (Indian Pharmacopoeia) specifications. 6-MP by Zydus ensures therapeutic reliability and high purity of the active pharmaceutical ingredient.
Key Features:
- ✅ Clinical Standard: An essential component of long-term maintenance therapy for Acute Lymphoblastic Leukemia.
- ✅ Dual Action: Provides both cytostatic (anti-cancer) and potent immunosuppressive effects.
- ✅ Bulk Packaging: Each box contains 100 tablets (10 blisters of 10), ideal for long-term treatment cycles.
Prescribed by a hematologist or oncologist for the treatment of:
- 🔹 Acute Lymphoblastic Leukemia (ALL): For induction of remission and as part of maintenance therapy regimens in both children and adults.
- 🔹 Acute Myeloid Leukemia (AML).
- 🔹 Chronic Myeloid Leukemia (CML).
- 🔹 Inflammatory Bowel Disease (IBD): Such as Crohn's disease and Ulcerative Colitis (used off-label when standard therapy is insufficient).
Sales Unit: Carton box containing 100 tablets (10 x 10 tablets). Strength: 50 mg per tablet.
⚠️ APPLICATION INSTRUCTIONS:
- Dosage: Must be strictly individualized by a physician based on body surface area (BSA) and weight. The usual starting dose is 2.5 mg/kg per day.
- Administration: Best taken in the evening, either 1 hour before or 2 hours after a meal. Consistency in daily administration is crucial.
- ✋ Safety Note: As a cytotoxic drug, use gloves when handling split tablets. Pregnant women must avoid any contact with the medication.
- ⛔ Severe Bone Marrow Suppression: Pre-existing low levels of white blood cells or platelets.
- Pregnancy and breastfeeding (potential teratogenic risk).
- Hypersensitivity to mercaptopurine or any tablet components.
- Caution in patients with TPMT enzyme deficiency (increased risk of life-threatening toxicity).
Treatment requires rigorous monitoring of full blood counts and liver function tests. Potential side effects include:
- 🩸 Hematologic: Leukopenia, thrombocytopenia, anemia (myelosuppression).
- 🟡 Hepatotoxicity: Cholestasis, jaundice, or elevated liver enzymes.
- 🦠 Immune System: Increased susceptibility to viral and bacterial infections.
- 🤢 Gastrointestinal: Nausea, vomiting, loss of appetite, stomatitis.
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