Indicated for the treatment of adult patients with: Chronic Lymphocytic Leukemia (CLL) / Small Lymphocytic Lymphoma (SLL): Both treatment-naive and relapsed/refractory cases. Mantle Cell Lymphoma (MCL): For patients who have received at least one prior therapy.

Dosage and administration

Standard Dosage: 100 mg capsule taken orally twice daily (approximately every 12 hours). ⚠️ CRITICAL INTERACTION WARNING (Stomach Acid): Acalabrutinib requires stomach acid for absorption. 🚫 AVOID PPIs: Do not take Proton Pump Inhibitors (e.g., Omeprazole, Esomeprazole, Pantoprazole). They drastically reduce the drug's effectiveness. ✅ H2 Blockers/Antacids: Take Acabrunat 2 hours before taking antacids (like Calcium Carbonate) or H2-blockers (like Famotidine).

Active serious bleeding. Upcoming surgery (Stop therapy 3–7 days pre- and post-surgery). Severe hepatic impairment. Pregnancy and breastfeeding. Concomitant use of Warfarin (increases bleeding risk).

Generally well-tolerated. Common adverse reactions include: Headache: Very common initially. Usually manageable with caffeine or mild analgesics and resolves over time. Diarrhea. Bruising: Increased tendency to bruise. Neutropenia (low white blood cell count).

Acabrunat — Acalabrutinib 100 mg, 30 pcs, Natco

100% original product

Active ingredient

Acalabrutinib

Manufacturer

Natco

Dosage 100 mg

Dosage form Capsules

Capsules per pack 30

Acabrunat (Acalabrutinib) 100 mg

Name: Acabrunat
Brand: Natco
SKU: PROD-71
Price: 8482 UAH
Availability: InStock

8482₴ ~~9229₴~~ -8%

Acabrunat is a next-generation targeted therapy for blood cancers. Active ingredient: Acalabrutinib (100 mg).

Manufacturer: Natco Pharma (India). Generic equivalent of Calquence.

The "Safer" BTK Inhibitor:

Acabrunat is a highly selective Bruton tyrosine kinase (BTK) inhibitor. Unlike the first-generation drug (Ibrutinib), it has less "off-target" activity. This means a significantly lower risk of cardiac arrhythmias (atrial fibrillation) and severe bleeding, making it a safer choice for elderly patients.

✅ Advantage: Powerful efficacy with fewer side effects.

Indicated for the treatment of adult patients with:

Chronic Lymphocytic Leukemia (CLL) / Small Lymphocytic Lymphoma (SLL): Both treatment-naive and relapsed/refractory cases.
Mantle Cell Lymphoma (MCL): For patients who have received at least one prior therapy.

Standard Dosage: 100 mg capsule taken orally twice daily (approximately every 12 hours).

⚠️ CRITICAL INTERACTION WARNING (Stomach Acid):

Acalabrutinib requires stomach acid for absorption.

🚫 AVOID PPIs: Do not take Proton Pump Inhibitors (e.g., Omeprazole, Esomeprazole, Pantoprazole). They drastically reduce the drug's effectiveness.
✅ H2 Blockers/Antacids: Take Acabrunat 2 hours before taking antacids (like Calcium Carbonate) or H2-blockers (like Famotidine).

Active serious bleeding.
Upcoming surgery (Stop therapy 3–7 days pre- and post-surgery).
Severe hepatic impairment.
Pregnancy and breastfeeding.
Concomitant use of Warfarin (increases bleeding risk).

Generally well-tolerated. Common adverse reactions include:

Headache: Very common initially. Usually manageable with caffeine or mild analgesics and resolves over time.
Diarrhea.
Bruising: Increased tendency to bruise.
Neutropenia (low white blood cell count).

Notice. The information on this page is for reference only and does not replace medical consultation. Always consult a healthcare professional and read the manufacturer's instructions before using any medicine. Self-medication may be dangerous. Information updated: 04.05.2026

Active ingredient

Acalabrutinib

Manufacturer

Natco

Dosage 100 mg

Dosage form Capsules

Capsules per pack 30

100% original product

Delivery across Ukraine

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