Adakras Tablets — Adagrasib 200 mg (42 Tabs) Everest

Prescribed by oncologists for the treatment of adult patients with:

• 🔹 Non-Small Cell Lung Cancer (NSCLC): KRAS G12C-mutated locally advanced or metastatic NSCLC, as determined by an approved test, who have received at least one prior systemic therapy.

Sales Unit: Bottle containing 42 film-coated tablets (200 mg strength).

⚠️ APPLICATION INSTRUCTIONS:

• Standard Dosage: 600 mg (three 200 mg tablets) taken orally twice daily. Total daily dose is 1200 mg.
• Administration: Swallow tablets whole with water. Can be taken with or without food. Take at approximately the same time each day. Do not chew, crush, or split.
• ✋ Missed Dose: If a dose is missed by more than 4 hours, skip it. Resume the regular schedule next time. Do not double up.
• 🤮 Vomiting: If vomiting occurs after taking a dose, do not take an additional dose. Wait for the next scheduled dose.

• ⛔ Pregnancy & Breastfeeding: Strictly contraindicated due to fetal toxicity. Effective contraception is mandatory.
• Hypersensitivity to Adagrasib.
• Co-administration with strong CYP3A4 inducers.
• Severe hepatic impairment requires caution.

Regular ECGs and liver function tests are required. Potential side effects include:

• 🤢 Gastrointestinal: Diarrhea (very common), nausea, vomiting. Hydration is important.
• 🔶 Hepatotoxicity: Elevated liver enzymes (ALT/AST).
• ❤️ Cardiac: QTc interval prolongation (heart rhythm changes).
• 🤧 Respiratory: Interstitial Lung Disease (ILD) / Pneumonitis (rare but serious).
• 🩸 Hematologic: Anemia, decreased white blood cell count.