Ascimib Tablets — Asciminib 40 mg (30 Tabs) Everest

Prescribed by hematologists for adult patients with:

• 🔹 Chronic Myeloid Leukemia (CML): In chronic phase (Ph+ CML-CP) previously treated with two or more tyrosine kinase inhibitors (e.g., imatinib, nilotinib, dasatinib).
• 🔹 T315I Mutation: Treatment of CML with the T315I mutation (requires different dosing strategies).

Sales Unit: Bottle containing 30 film-coated tablets (40 mg strength).

⚠️ APPLICATION INSTRUCTIONS:

• Standard Dosage: Typically 80 mg daily (taken as 40 mg twice daily approximately 12 hours apart, or 80 mg once daily, as prescribed).
• Fasting Requirement: Must be taken on an empty stomach. Avoid food for at least 2 hours before and 1 hour after taking the dose. Food significantly reduces absorption.
• Administration: Swallow tablets whole with water. Do not chew or crush.
• ✋ Missed Dose: If more than 6 hours have passed (for twice-daily regimen), skip the missed dose. Do not double up.

• ⛔ Pregnancy & Breastfeeding: Strictly contraindicated due to potential fetal harm.
• Hypersensitivity to Asciminib.
• History of pancreatitis (requires monitoring of pancreatic enzymes).
• Pediatric patients (safety not established).

Regular blood tests are required. Potential side effects include:

• 🩸 Hematologic: Thrombocytopenia (low platelets), neutropenia, anemia.
• 🦴 Musculoskeletal: Pain in muscles, joints, or bones.
• 🤯 General: Fatigue, headache.
• 🩺 Labs/Vitals: Elevated pancreatic enzymes (amylase/lipase), liver enzymes, hypertension.