Dacilon (Dactinomycin) 0.5 mg

Indicated for the treatment of:

• Wilms' Tumor: Often part of a curative regimen in children.
• Rhabdomyosarcoma: Childhood muscle cancer.
• Gestational Trophoblastic Neoplasia: Choriocarcinoma (uterine cancer).
• Ewing's Sarcoma.

⚠️ DANGER: For Intravenous (IV) Use ONLY!

Dacilon is an extremely potent vesicant. Extravasation (leakage) into subcutaneous tissue causes severe necrosis (tissue death).

Administration Guide:

• 💉 Inject into the tubing of a rapidly flowing IV infusion (saline or glucose).
• Avoid inhalation of powder or contact with skin during preparation.

Dosage: Calculated in micrograms (mcg) based on Body Surface Area (BSA) or body weight. Dosages for obese patients should be capped.

• Chickenpox (Varicella) or Herpes Zoster: Administration during these infections can be fatal due to systemic spread.
• Severe bone marrow depression.
• Pregnancy and breastfeeding.
• Infants under 6 months.

Adverse reactions are common and can be severe:

• Gastrointestinal: Severe nausea and vomiting occur shortly after administration (antiemetics are required).
• Dermatologic: Alopecia (hair loss), acne, and "Radiation Recall" phenomenon (redness/burns returning to previously irradiated skin areas).
• Hematologic: Bone marrow suppression (nadir usually occurs 1-3 weeks after therapy).