Jakavi 20 — Ruxolitinib 20 mg (56 Tablets)

Jakavi is prescribed by hematologists for the treatment of the following conditions:

• 🔹 Myelofibrosis: Including primary myelofibrosis, post-polycythemia vera myelofibrosis, and post-essential thrombocythemia myelofibrosis in adult patients.
• 🔹 Polycythemia Vera: In patients who are resistant to or intolerant of hydroxyurea therapy.
• 🔹 Graft-Versus-Host Disease (GVHD): Treatment of acute or chronic forms of the disease in patients with an inadequate response to corticosteroids.

Sales Form: 1 pack contains 56 tablets of 20 mg.

⚠️ INSTRUCTIONS FOR USE:

• Dosage Regimen: The dosage is selected strictly individually by a physician based on platelet and hemoglobin levels. Usually, the drug is taken twice daily (every 12 hours).
• Method: Tablets should be swallowed whole with water. They can be taken with or without food.
• Monitoring: During treatment, it is necessary to regularly perform a complete blood count to monitor platelet and white blood cell levels.
• Discontinuation of Therapy: Do not abruptly stop taking the medication without consulting a doctor, as this may cause a relapse of symptoms.
• Storage: Store at a temperature not exceeding 30°C in a dry place.

• ⛔ Hypersensitivity: Allergy to ruxolitinib or any other components of the tablets.
• ⛔ Pregnancy and Planning: The drug is contraindicated for pregnant women. Women of childbearing age should use reliable methods of contraception.
• ⛔ Lactation: Breastfeeding must be completely discontinued during therapy.
• ⛔ Laboratory Tests: Severe thrombocytopenia or neutropenia (low blood cell counts) before starting treatment require caution or delay of therapy.
• ⛔ Infections: Presence of severe active infections until they are cured.

Most frequently observed side effects requiring medical monitoring:

• 🩸 Hematology: Anemia, thrombocytopenia (low platelet count), neutropenia.
• 🤒 Infections: Increased risk of urinary tract infections, herpes zoster (shingles), flu-like conditions.
• 🧪 Metabolism: Increased blood cholesterol levels, weight gain.
• 🧠 Neurology: Dizziness, frequent headaches.
• ⚠️ Important: If unexplained bleeding, bruising, sudden fever, or a painful skin rash occurs, contact a hematologist immediately.