Ponaxen 15 (Ponatinib) 15 mg Tablets
15390₴
18468₴
-17%
Ponaxen 15 mg (Ponatinib) is a tyrosine kinase inhibitor used for the treatment of resistant leukemias associated with BCR-ABL mutations.
Manufacturer: Everest Pharmaceuticals Ltd.. Each pack contains 30 tablets. It is active against a broad range of BCR-ABL mutations, including the highly resistant T315I mutation.
Key Feature:
The 15 mg strength is useful for individualized dose adjustment, dose reduction after treatment response, or for improving safety in patients at risk of serious vascular adverse events.
Indicated for the treatment of adult patients with:
- 🔹 Chronic Myeloid Leukemia (CML): in chronic, accelerated, or blast phase in patients resistant or intolerant to other tyrosine kinase inhibitors.
- 🔹 Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL): when prior therapy has failed or is not appropriate.
- 🔹 T315I mutation: in patients with confirmed BCR-ABL T315I mutation.
Packaging: 15 mg tablets.
⚠️ ADMINISTRATION PROTOCOL:
- Dose: Determined individually by the treating physician. The 15 mg tablet is often used for reduced maintenance dosing or stepwise dose adjustment.
- Food Intake: Can be taken with or without food.
- Administration: Swallow the tablet whole with water.
- Monitoring: Regular monitoring of blood counts, liver function, lipase, blood pressure, and cardiovascular status is required.
- Note: Use only under the supervision of a hematologist or oncologist.
- Hypersensitivity to Ponatinib or any excipient of the product.
- Pregnancy and breastfeeding.
- Use in children under 18 years of age is not established.
- Use with caution in patients with hypertension, ischemic heart disease, thrombosis, hepatic impairment, or pancreatitis.
Common and clinically important adverse reactions include:
- 🩸 Cardiovascular: Increased blood pressure, thromboembolic events, vascular occlusion.
- 📉 Gastrointestinal: Nausea, vomiting, abdominal pain, diarrhea or constipation.
- 🦠 Hematologic: Anemia, neutropenia, thrombocytopenia.
- ⚠️ Liver/Pancreas: Elevated liver enzymes, pancreatitis, increased lipase.
- 💢 General: Weakness, headache, skin rash, fatigue.
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