Selinex — Selinexor 20 mg Tablets

Prescribed by hematologists or oncologists for complex hematologic malignancies:

• 🔹 Multiple Myeloma: For patients with relapsed or refractory disease who have received at least one prior therapy. Usually administered in combination with dexamethasone.
• 🔹 Diffuse Large B-Cell Lymphoma (DLBCL): For adult patients with relapsed or refractory disease after at least two lines of systemic therapy.

Sales Unit: Bottle containing 16 tablets of 20 mg.

⚠️ DOSING AND SUPPORTIVE CARE:

• Dosing Schedule: The dose and specific days (usually once or twice weekly) are determined by the physician.
• Nausea Prevention: Prophylactic antiemetics (5-HT3 antagonists) are mandatory prior to taking Selinexor, as nausea is a very common side effect.
• Administration: Swallow tablets whole with water. Can be taken with or without food.
• ⛔ Important: Do not break, chew, or crush the tablets.

• ⛔ Pregnancy and Breastfeeding: Can cause fetal harm.
• Severe hyponatremia (critically low sodium levels).
• Active severe infections.
• Children (under 18 years of age).
• Hypersensitivity to Selinexor.

Weekly blood tests and sodium level monitoring are required. Potential side effects:

• 🩸 Thrombocytopenia: Low platelet count (risk of bleeding).
• 🤢 Gastrointestinal: Nausea, vomiting, diarrhea, decreased appetite, and weight loss (nutritional support may be needed).
• 📉 General: Severe fatigue (asthenia).
• 🧪 Hyponatremia: Low sodium levels in the blood (may require salt tablets or IV fluids).