Zirabev 400 Vial — Bevacizumab 400 mg/16 ml (1 Vial) Pfizer

Prescribed by an oncologist, either as a monotherapy or in combination with chemotherapy, for the treatment of:

• 🔹 Metastatic colorectal cancer.
• 🔹 Advanced, metastatic, or recurrent non-squamous non-small cell lung cancer (NSCLC).
• 🔹 Advanced and/or metastatic renal cell carcinoma (kidney cancer).
• 🔹 Glioblastoma (a recurrent malignant brain tumor).
• 🔹 Epithelial ovarian, fallopian tube, or primary peritoneal cancer, and cervical cancer.

Sales Unit: Carton containing 1 glass vial of concentrate for solution for infusion (400 mg / 16 ml).

⚠️ APPLICATION INSTRUCTIONS:

• Intravenous Infusion ONLY: The drug must be administered only as an intravenous (IV) drip by a qualified healthcare professional in a clinical setting. It must NEVER be administered as an IV push or bolus!
• Dosage: Calculated individually by the doctor based on the patient's body weight and the specific treatment protocol (typically 5 mg, 7.5 mg, 10 mg, or 15 mg per kg of body weight, given every 2 or 3 weeks).
• Preparation: The vial must be diluted with normal saline (0.9% sodium chloride) prior to administration.

• ⛔ Recent Surgery: Strictly contraindicated for at least 28 days following major surgery or until the surgical wound has fully healed (the drug impairs tissue healing).
• ⛔ Bleeding: Patients with a history of severe hemorrhage or recent coughing up of blood (hemoptysis).
• Pregnancy and breastfeeding (causes severe fetal harm).
• Hypersensitivity to bevacizumab or any other recombinant human or humanized antibodies.

Therapy must be conducted under the strict supervision of an oncologist. Potential side effects include:

• 🫀 Cardiovascular: High blood pressure (hypertension) is very common and requires monitoring and possible blood pressure medication. Increased risk of blood clots (thromboembolism).
• 🩸 Bleeding: Increased risk of hemorrhage (ranging from nosebleeds to severe internal bleeding).
• ⚠️ Gastrointestinal: Risk of gastrointestinal perforation (a rare but severe complication).
• 🟡 Kidneys: Excess protein in the urine (proteinuria).
• 💤 General: Impaired wound healing, asthenia (severe weakness), fatigue.