Tofajak Ointment — Tofacitinib 2% (15 g)
Tofajak Ointment (Tofacitinib 2%) is an innovative topical medication belonging to the class of Janus kinase (JAK) inhibitors. The active substance — tofacitinib at a 2% concentration — effectively blocks intracellular signaling pathways of inflammation, which play a key role in the development of many autoimmune skin diseases.
Manufacturer: Cipla, India. Tofajak ointment represents an advanced solution in dermatology, allowing the active ingredient to be delivered directly to the focus of inflammation. This minimizes systemic impact on the body compared to oral forms while maintaining high therapeutic efficacy in treating complex dermatological conditions.
Key Features:
- ✅ Targeted Therapy: Specifically acts on the JAK-STAT pathway, suppressing immune system hyperactivity in skin tissues.
- ✅ High Concentration: The 2% active ingredient content ensures deep penetration and a pronounced anti-inflammatory effect.
- ✅ Safe Profile: Topical application significantly reduces the risk of side effects related to internal organs and blood.
Tofajak Ointment 2% is prescribed by dermatologists for the treatment of the following conditions:
- 🔹 Atopic Dermatitis: Treatment of moderate-to-severe forms in adults when traditional therapy is insufficiently effective.
- 🔹 Vitiligo: Stimulation of skin repigmentation by suppressing the immune attack on melanocytes.
- 🔹 Alopecia Areata: Stimulation of hair growth in affected areas of the scalp and body.
- 🔹 Psoriasis: Reduction of plaque area, relief of itching and inflammation in plaque psoriasis.
Sales Form: The tube contains 15 g of ointment with a tofacitinib concentration of 2%.
⚠️ INSTRUCTIONS FOR USE:
- Application Method: Apply a thin layer only to the affected areas of the skin.
- Dosage Regimen: Usually applied 2 times a day (morning and evening).
- Precautions: Wash your hands thoroughly after applying the ointment unless the hands are the area being treated. Avoid contact with mucous membranes and eyes.
- Course Duration: Determined individually by a physician depending on the disease dynamics.
- Storage: Store at temperatures up to 25°C in a dry place. Do not freeze. Keep the tube tightly closed.
- ⛔ Skin Infections: Presence of active bacterial, viral (herpes, chickenpox), or fungal infections at the site of application.
- ⛔ Pregnancy and Lactation: Use is not recommended due to lack of sufficient data on safety for the fetus and child.
- ⛔ Hypersensitivity: Allergy to tofacitinib or any inactive components of the ointment base.
- ⛔ Severe Systemic Infections: Use with caution in the presence of active tuberculosis or viral hepatitis.
- ⛔ Age: Use in children and adolescents must be strictly monitored by a physician.
The drug is generally well-tolerated as it acts locally; however, the following reactions are possible:
- 🔥 Local Reactions (most common): Mild burning, itching, redness, or tingling at the application site during the first minutes after use.
- 🧴 Skin Condition: Folliculitis (inflammation of hair follicles), acne-like eruptions, or skin dryness.
- 🤕 Systemic Effects (rare): When applied to very large areas, headache or nasopharyngitis (cold symptoms) may occur.
- ⚠️ Important: If signs of a severe allergic reaction (swelling, severe rash) or signs of skin infection appear, discontinue use and consult your attending physician.
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