CA ATRA-10 (Tretinoin) 10 mg

Indicated for the induction of remission in patients with:

• Acute Promyelocytic Leukemia (APL): FAB classification M3. Used for both newly diagnosed patients and those who have relapsed.

Strength: 10 mg Soft Gelatin Capsules.

Standard Dosage: 45 mg/m²/day administered in two evenly divided doses until complete remission is achieved (usually up to 90 days).

⚠️ Administration Instructions:

• 🍲 Take with food. Absorption is enhanced by fats.
• Swallow whole; do not chew.
• Consistency is key: Take at the same times each day.

🚫 BLACK BOX WARNING: PREGNANCY (Category X).

There is an extremely high risk that Tretinoin will cause severe birth defects. Effective contraception is mandatory for all female patients of childbearing potential.

Drug Interactions:

• Avoid Vitamin A supplements (Hypervitaminosis A risk).
• Avoid Tetracyclines (Risk of Intracranial Hypertension).

Critical Warning: Retinoic Acid Syndrome (RAS).

Symptoms include fever, dyspnea, acute respiratory distress, weight gain, and edema. Immediate medical attention is required.

Common side effects:

• Dry skin, chapped lips, dry nose/eyes.
• Headache (Pseudotumor cerebri).
• Bone pain and nausea.