Vesanoid (Tretinoin) 10 mg

Indicated for the induction of remission in patients with:

• Acute Promyelocytic Leukemia (APL): Characterized by the t(15;17) translocation. Used for both newly diagnosed and relapsed patients.

Strength: 10 mg soft gelatin capsule.

Standard Dosage: 45 mg/m²/day administered in two evenly divided doses.

⚠️ Administration Instructions:

• 🍲 Take with food. Absorption is significantly enhanced by food.
• Do not crush or chew.
• Therapy usually continues for 30 to 90 days until complete remission is achieved.

🚫 BLACK BOX WARNING: PREGNANCY.

There is an extremely high risk that Tretinoin will cause severe birth defects if pregnancy occurs while taking it. Effective contraception is mandatory for all patients of childbearing potential.

Drug Interactions:

• Do NOT take with Vitamin A supplements (risk of hypervitaminosis A).
• Do NOT take with Tetracyclines (risk of pseudotumor cerebri/intracranial hypertension).

Critical Warning: Retinoic Acid Syndrome (RAS).

Watch for fever, dyspnea (shortness of breath), weight gain, or edema. This condition can be fatal if not treated immediately with corticosteroids.

Other common effects:

• Dry skin, chapped lips (Cheilitis), dry eyes.
• Headache (severe headaches may indicate intracranial pressure).
• Bone pain.