Caboxen 20 (Cabozantinib) 20 mg Capsules
23305₴
24624₴
-5%
Caboxen 20 mg (Cabozantinib) is a potent multi-targeted tyrosine kinase inhibitor (TKI) that acts against VEGFR, MET, and AXL receptors to inhibit tumor growth and angiogenesis.
Manufacturer: Everest Pharmaceuticals. Each pack contains 90 capsules. It is designed to treat cancers that may be resistant to other therapies by blocking multiple pathways involved in cancer progression and metastasis.
Key Feature:
Known for its dual mechanism of action, targeting both the tumor cells directly and their blood supply, making it effective in advanced stages of kidney and liver cancer.
Indicated for the treatment of adult patients with:
- 🔹 Advanced Renal Cell Carcinoma (RCC): For patients with advanced kidney cancer (first-line or after prior anti-angiogenic therapy).
- 🔹 Hepatocellular Carcinoma (HCC): For patients with liver cancer who have previously been treated with sorafenib.
- 🔹 Medullary Thyroid Cancer (MTC): For progressive, metastatic medullary thyroid cancer.
Packaging: 20 mg capsules.
⚠️ ADMINISTRATION PROTOCOL:
- Dosage: Prescribed by a doctor (typically 60 mg to 140 mg daily depending on the type of cancer). The 20 mg capsule allows for dose adjustments.
- Food Intake: ⛔ Must be taken on an empty stomach. Do not eat for at least 2 hours before and 1 hour after taking the drug.
- Administration: Swallow capsules whole with a full glass of water. Do not crush or chew.
- Warning: Avoid grapefruit and grapefruit juice while taking this medication.
- Hypersensitivity to Cabozantinib.
- History of severe hemorrhage or gastrointestinal perforation/fistula.
- Severe hepatic or renal impairment.
- Pregnancy and breastfeeding.
Common adverse reactions include:
- 🩸 Cardiovascular: Hypertension (high blood pressure), hemorrhage events.
- 📉 Gastrointestinal: Diarrhea (very common), nausea, decreased appetite, dysgeusia (taste distortion).
- 🖐 Dermatologic: Palmar-plantar erythrodysesthesia (Hand-foot syndrome - redness, pain, or blisters on hands/feet).
- 🌀 General: Fatigue, weight loss, asthenia.
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