Hepanib (Sorafenib) Tablets
Hepanib 200 mg (Sorafenib) is an oral multikinase inhibitor used for targeted cancer therapy.
Manufacturer: Everest Pharmaceuticals. Each pack contains 28 tablets. Sorafenib works by blocking signals that tell cancer cells to grow and by preventing the formation of new blood vessels that tumors need to survive (angiogenesis inhibition).
Clinical Value:
It is a first-line systemic therapy for patients with advanced liver cancer and advanced kidney cancer, helping to control disease progression.
Indicated for the treatment of:
- 🧬 Hepatocellular Carcinoma (Liver Cancer): For patients with unresectable pathology.
- 🧬 Renal Cell Carcinoma (Kidney Cancer): For patients with advanced disease who have failed prior interferon-alpha or interleukin-2 based therapy.
- 🧬 Differentiated Thyroid Carcinoma: For progressive, radioactive iodine-refractory thyroid cancer.
Packaging: 200 mg film-coated tablets.
⚠️ ADMINISTRATION PROTOCOL:
- Standard Dose: 400 mg (2 tablets) taken twice daily. Total daily dose is 800 mg.
- Administration: Take without food (at least 1 hour before eating) or with a low-fat or moderate-fat meal. Do not take with high-fat meals. Swallow whole with water.
- Duration: Treatment continues as long as clinical benefit is observed or until unacceptable toxicity occurs.
- Hypersensitivity to Sorafenib or any component of the formulation.
- Pregnancy and breastfeeding (can cause fetal harm).
- Severe cardiovascular events (e.g., recent myocardial infarction).
- Active bleeding or bleeding diathesis.
Common adverse reactions include:
- ✋ Dermatologic: Hand-foot skin reaction (redness, pain, swelling, or blisters on palms/soles), rash, alopecia.
- 🤢 Gastrointestinal: Diarrhea, nausea, vomiting.
- 📉 Cardiovascular/General: Hypertension (high blood pressure), fatigue, weight loss.
- Blood pressure should be monitored regularly during treatment.
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