Lucicriz Capsules — Crizotinib 250 mg (60 Caps) Lucius

Strictly prescribed by an oncologist following biomarker testing of the tumor. Indicated for the treatment of adult patients with:

• 🔹 Metastatic Non-Small Cell Lung Cancer (NSCLC):
  • Whose tumors are ALK-positive.
  • Whose tumors are ROS1-positive.

Sales Unit: Plastic bottle in a carton box containing 60 capsules. Strength: 250 mg per capsule.

⚠️ APPLICATION INSTRUCTIONS:

• Standard Dosage: The recommended dose is 250 mg (1 capsule) taken twice daily (morning and evening).
• Administration: Take at approximately the same times each day, with or without food. Swallow capsules whole; do not crush, open, or chew them.
• ✋ Crucial Dietary Warning: Strictly avoid consuming grapefruit or grapefruit juice during treatment, as it can dangerously increase the concentration of Crizotinib in the body.

• ⛔ Pregnancy and Breastfeeding: Can cause fetal harm. Highly effective contraception must be used by both men and women during treatment and for at least 90 days after the last dose.
• Severe hepatic impairment.
• Congenital long QT syndrome.
• Children and adolescents under 18 years of age.

A hallmark side effect of Crizotinib is visual impairment (very common, usually occurring early in treatment). Potential adverse reactions include:

• 👁️ Vision Disorders: Flashes of light, blurred vision, double vision, or floaters (usually transient or manageable with dose adjustment).
• 🤢 Gastrointestinal: Nausea, vomiting, diarrhea, constipation.
• 💧 Edema: Peripheral edema (swelling of the hands, feet, or face).
• 🔶 Liver: Hepatotoxicity/elevated liver enzymes (requires regular blood monitoring).
• ❤️ Cardiac: Decreased heart rate (bradycardia).