Indicated for CD20-positive conditions: 🩸 Non-Hodgkin’s Lymphoma (NHL): Follicular lymphoma and Diffuse Large B-Cell Lymphoma (DLBCL). 🩸 Chronic Lymphocytic Leukemia (CLL): First-line and relapsed/refractory treatment. 🦴 Rheumatoid Arthritis (RA): Moderate to severe active RA in patients with inadequate response to TNF inhibitors. Granulomatosis with Polyangiitis (GPA).

Dosage and administration

Packaging: 50 ml Vial (Concentration 10 mg/ml = Total 500 mg). ⚠️ ADMINISTRATION & SAFETY: 💉 IV Infusion Only: Must be administered via a dedicated line. NEVER administer as an IV push or bolus. 💊 Premedication: Antipyretics (e.g., paracetamol) and antihistamines (e.g., diphenhydramine) must be given before each infusion to reduce reactions. ⏱ Rate: Infusion starts slowly and rate is increased gradually if well-tolerated.

Active, severe infections (e.g., tuberculosis, sepsis). Severe heart failure (NYHA Class IV). Known hypersensitivity to murine proteins. Pregnancy and breastfeeding (unless benefit outweighs risk).

Critical monitoring required for: 🚨 Infusion-Related Reactions (IRRs): Fever, chills, rigor, hypotension (very common during the first dose). 🦠 Infections: Reactivation of Hepatitis B virus (screening is mandatory before starting therapy). 📉 Hematologic: Neutropenia, leukopenia. PML (Progressive Multifocal Leukoencephalopathy) - rare but serious.

Maball 500 — Rituximab 500 mg / 50 ml, 1 pcs, Hetero

100% original product

Active ingredient

Rituximab

Manufacturer

Hetero

Dosage 500 mg / 50 ml

Dosage form Vial

Vials per pack 1

Maball 500 (Rituximab) 500 mg/50 mL

Name: Maball 500
Brand: Hetero
SKU: PROD-114
Price: 7691 UAH
Availability: InStock

7691₴ ~~8570₴~~ -10%

Maball 500 (Rituximab 500 mg/50 ml) is a chimeric monoclonal antibody targeting CD20 antigen.

Manufacturer: Hetero Healthcare (India). It is a biosimilar to MabThera/Rituxan. The 500 mg vial serves as a convenient high-dose option for oncology protocols.

Mechanism of Action ("Search and Destroy"):

Rituximab specifically binds to the CD20 transmembrane antigen found on pre-B and mature B lymphocytes. Once bound, it triggers the body's immune defenses (CDC and ADCC mechanisms) to attack and lyse (break down) these cells. By depleting B-cells, it treats both B-cell malignancies and autoimmune disorders driven by B-cell activity.

✅ Key Benefit: Standard-of-care efficacy in treating CD20-positive lymphomas and leukemias.

Indicated for CD20-positive conditions:

🩸 Non-Hodgkin’s Lymphoma (NHL): Follicular lymphoma and Diffuse Large B-Cell Lymphoma (DLBCL).
🩸 Chronic Lymphocytic Leukemia (CLL): First-line and relapsed/refractory treatment.
🦴 Rheumatoid Arthritis (RA): Moderate to severe active RA in patients with inadequate response to TNF inhibitors.
Granulomatosis with Polyangiitis (GPA).

Packaging: 50 ml Vial (Concentration 10 mg/ml = Total 500 mg).

⚠️ ADMINISTRATION & SAFETY:

💉 IV Infusion Only: Must be administered via a dedicated line. NEVER administer as an IV push or bolus.
💊 Premedication: Antipyretics (e.g., paracetamol) and antihistamines (e.g., diphenhydramine) must be given before each infusion to reduce reactions.
⏱ Rate: Infusion starts slowly and rate is increased gradually if well-tolerated.

Active, severe infections (e.g., tuberculosis, sepsis).
Severe heart failure (NYHA Class IV).
Known hypersensitivity to murine proteins.
Pregnancy and breastfeeding (unless benefit outweighs risk).

Critical monitoring required for:

🚨 Infusion-Related Reactions (IRRs): Fever, chills, rigor, hypotension (very common during the first dose).
🦠 Infections: Reactivation of Hepatitis B virus (screening is mandatory before starting therapy).
📉 Hematologic: Neutropenia, leukopenia.
PML (Progressive Multifocal Leukoencephalopathy) - rare but serious.

Notice. The information on this page is for reference only and does not replace medical consultation. Always consult a healthcare professional and read the manufacturer's instructions before using any medicine. Self-medication may be dangerous. Information updated: 18.03.2026

Active ingredient

Rituximab

Manufacturer

Hetero

Dosage 500 mg / 50 ml

Dosage form Vial

Vials per pack 1

100% original product

Delivery across Ukraine

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