Ofev 100 — Nintedanib 100 mg (60 Capsules)
Ofev 100 mg (Nintedanib) is a modern anti-fibrotic medication designed to slow the progression of severe interstitial lung diseases. Nintedanib blocks the activity of specific receptors (tyrosine kinases) that stimulate the growth and division of fibroblasts — cells responsible for the formation of scar tissue in the lungs. The 100 mg dosage allows the physician to individually tailor effective therapy, ensuring a balance between therapeutic action and drug tolerability.
Manufacturer: Boehringer Ingelheim, Germany. Ofev is the standard of care for fibrosing lung diseases, helping patients preserve respiratory function and reduce the risk of exacerbations that lead to a sharp deterioration in health.
Key Features:
- ✅ Therapeutic Flexibility: The 100 mg dosage is often used for patients with increased sensitivity to the drug or when dose adjustment is necessary due to side effects.
- ✅ Targeted Mechanism: Acts directly on the mechanisms of pulmonary fibrosis formation (VEGFR, FGFR, PDGFR).
- ✅ Clinically Proven Effect: Significantly slows the annual decline in forced vital capacity (FVC).
Ofev 100 mg is prescribed by pulmonologists for long-term therapy of the following conditions:
- 🔹 Idiopathic Pulmonary Fibrosis (IPF): A chronic disease in which lung tissue is replaced by scar tissue.
- 🔹 Progressive Fibrosing Interstitial Lung Diseases (ILD): To slow the process of lung tissue scarring.
- 🔹 Systemic Sclerosis: Treatment of systemic sclerosis-associated interstitial lung disease (SSc-ILD).
Sales Form: 1 pack contains 60 soft capsules of 100 mg.
⚠️ INSTRUCTIONS FOR USE:
- Dosage Regimen: While the standard dose with good tolerability is 150 mg twice daily, when the 100 mg dosage is prescribed, the drug is taken as 1 capsule (100 mg) twice daily (morning and evening) with a 12-hour interval.
- Method: Capsules should be taken with food, swallowed whole. They must not be chewed or opened, as the contents have a bitter taste and irritate the mucous membranes.
- Liver Function Monitoring: Regular monitoring of liver enzymes (ALT, AST, bilirubin) is required before and during therapy.
- Storage: Store at a temperature not exceeding 25°C in a dry place.
- ⛔ Pregnancy: Nintedanib has toxic effects on the fetus. It is strictly contraindicated in pregnant women.
- ⛔ Hepatic Impairment: Severe and moderate hepatic insufficiency (Child-Pugh classes B and C).
- ⛔ Hypersensitivity: Allergy to nintedanib, peanuts, or soy.
- ⛔ Age: The drug is not intended for children and adolescents under 18 years of age.
- ⛔ Lactation: Breastfeeding should be discontinued during the treatment period.
Tolerability of the 100 mg dosage is usually higher, but the following side effects may be observed:
- 🤢 Gastrointestinal Tract: Diarrhea (most common), nausea, vomiting, abdominal pain, decreased appetite.
- 🧪 Liver: Increased levels of liver transaminases in the blood.
- 🩸 Vessels and Heart: Risk of arterial thromboembolism, increased blood pressure.
- 📉 Metabolism: Weight loss.
- ⚠️ Important: If diarrhea occurs, start taking anti-diarrheal agents immediately and inform your doctor. The 100 mg dosage is often used specifically to reduce the intensity of these symptoms.
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