Ofev 150 — Nintedanib 150 mg (60 Capsules)

Ofev 150 mg is used for the pathogenetic treatment of adult patients with the following diagnoses:

• 🔹 Idiopathic Pulmonary Fibrosis (IPF): To slow the progression of scarring in the lung tissue.
• 🔹 Progressive Fibrosing Interstitial Lung Diseases (ILD): With a chronic course phenotype.
• 🔹 Systemic Sclerosis: Treatment of systemic sclerosis-associated interstitial lung disease (SSc-ILD).

Sales Form: 1 pack contains 60 soft capsules of 150 mg.

⚠️ INSTRUCTIONS FOR USE:

• Dosage Regimen: The standard dose is 150 mg (1 capsule) twice daily (morning and evening) with a 12-hour interval.
• Method: Capsules should be taken orally with food, swallowed whole. Do not chew, break, or open the capsule.
• Monitoring: During Ofev 150 therapy, it is necessary to regularly (once a month at the beginning of treatment) check liver function tests (ALT, AST, bilirubin).
• Dose Adjustment: In case of severe side effects (e.g., severe diarrhea), the doctor may temporarily reduce the dose to 100 mg or suspend treatment.
• Storage: Store at a temperature not exceeding 25°C in the original packaging to protect from moisture.

• ⛔ Pregnancy: Nintedanib has teratogenic effects. Use during pregnancy is strictly prohibited.
• ⛔ Hepatic Impairment: Moderate to severe hepatic insufficiency (Child-Pugh classes B and C).
• ⛔ Allergy: Hypersensitivity to nintedanib, as well as to peanuts or soy (excipients in the capsule composition).
• ⛔ Age: Not for use in children and adolescents under 18 years of age.
• ⛔ Lactation: Breastfeeding should be discontinued during the therapy period.

When using the 150 mg dosage, side effects are common, but in most cases, they are manageable:

• 🤢 Gastrointestinal Tract: Diarrhea (most common), nausea, vomiting, decreased appetite, abdominal pain.
• 🧪 Liver: Increased levels of liver transaminases (ALT/AST).
• 🩸 Vessels: Increased blood pressure; in rare cases — risk of thromboembolic complications.
• 📉 Weight: Weight loss due to gastrointestinal disorders.
• ⚠️ Important: If diarrhea occurs, it is recommended to immediately start taking anti-diarrheal agents (loperamide) and increase fluid intake. If symptoms persist, consult a physician.