Sprycel Tablets — Dasatinib 50 mg (60 Tablets) Bristol-Myers Squibb
Sprycel 50 mg (Dasatinib) is a high-potency targeted anticancer therapy and a second-generation tyrosine kinase inhibitor (TKI). It is designed to inhibit a wide range of kinases, including BCR-ABL and the SRC family kinases. Sprycel suppresses the growth and proliferation of malignant bone marrow cells by targeting the pathological signaling pathways driven by the "Philadelphia chromosome" (Ph+). Its high affinity for kinase targets makes it effective even in cases of imatinib resistance.
Manufacturer: Bristol-Myers Squibb (BMS). Sprycel is the original innovator drug, backed by extensive clinical trials that have established its high efficacy and safety profile. It is manufactured according to the originator's rigorous global quality standards.
Key Features:
- ✅ Dual Inhibition Mechanism: Blocks both BCR-ABL and SRC-family kinases, reducing the likelihood of tumor resistance.
- ✅ Potent Binding: Binds to tyrosine kinase in both its active and inactive conformations.
- ✅ Overcoming Resistance: Proven effective for patients who have developed resistance to first-generation TKI therapy.
Sprycel is indicated for the treatment of adult patients with:
- 🔹 Newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in the chronic phase.
- 🔹 Chronic, accelerated, or blast phase Ph+ CML with resistance or intolerance to prior therapy, including imatinib.
- 🔹 Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with resistance or intolerance to prior therapy.
Sales Unit: 1 bottle containing 60 tablets of 50 mg Dasatinib.
⚠️ APPLICATION INSTRUCTIONS:
- Dosage: For chronic phase CML, the standard dose is 100 mg (two 50 mg tablets) once daily. For advanced phases of CML or Ph+ ALL, the dose is typically 140 mg once daily.
- Method: Swallow tablets whole. May be taken with or without food at the same time each day (morning or evening).
- Caution: Do not crush or break the tablets. Active ingredients may cause skin irritation if handled improperly.
- Storage: Store at room temperature (15°C to 30°C) in a dry environment.
- ⛔ Pregnancy and Breastfeeding: Known to cause fetal harm. Strictly contraindicated during pregnancy and nursing.
- ⛔ Drug Interactions: Concurrent use with antacids or proton pump inhibitors (PPIs) should be avoided as they decrease absorption.
- Hypersensitivity to Dasatinib or any of its excipients.
- Pediatric use (unless specified by pediatric CML treatment protocols).
Professional medical supervision and regular blood monitoring are essential. Potential side effects include:
- 🧪 Myelosuppression: Decreased platelet, neutrophil, and hemoglobin counts.
- 💧 Fluid Retention: Peripheral edema, pleural effusion (fluid around the lungs), and pericardial effusion.
- 🤢 Gastrointestinal: Diarrhea, nausea, and abdominal pain.
- 🩸 Hemorrhage: Risk of gastrointestinal and other bleeding events, often associated with low platelets.
- 🏃♂️ General: Fatigue, headache, and skin rash.
What Customers Say
No reviews yet
Your review can be the first!