Ventoxen 100 — Venetoclax 100 mg Tablets
30372₴
34711₴
-13%
Ventoxen 100 mg (Venetoclax) is a cutting-edge targeted therapy drug and a generic equivalent to Venclexta. It is a first-in-class BCL-2 inhibitor that induces programmed cell death (apoptosis) in cancer cells.
Manufacturer: Everest Pharmaceuticals (Bangladesh). ⚠️ Note: Contains 60 tablets per bottle. The drug demonstrates high efficacy even in patients who have relapsed or are refractory to previous chemotherapy treatments.
Key Features:
- ✅ Mechanism of Action: Blocks the BCL-2 protein, which cancer cells use to survive, effectively forcing the tumor to self-destruct.
- ✅ Targeted Therapy: Works systemically to clear leukemia cells from the blood and bone marrow.
- ✅ Accessibility: A high-quality generic from Everest makes this life-saving therapy more affordable.
Prescribed by hematologists/oncologists for:
- 🔹 Chronic Lymphocytic Leukemia (CLL): Either as monotherapy or in combination with Rituximab/Obinutuzumab.
- 🔹 Acute Myeloid Leukemia (AML): In newly diagnosed adults who are ineligible for intensive chemotherapy (combined with azacitidine or decitabine).
- 🔹 Small Lymphocytic Lymphoma (SLL).
Sales Unit: 1 Bottle (60 Tablets of 100 mg).
⚠️ STRICT DOSING SCHEDULE REQUIRED:
- Ramp-Up Phase: Therapy must NEVER start at 100 mg or 400 mg immediately! The dose is gradually increased over 5 weeks (starting at 20 mg) to prevent fatal Tumor Lysis Syndrome (TLS).
- Maintenance Dose: Typically 400 mg (four 100 mg tablets) once daily.
- Administration: Swallow tablets whole with a meal and water. Do not chew or crush.
- Missed Dose: If within 8 hours, take immediately. If more than 8 hours, skip and resume the next day.
- ⛔ Tumor Lysis Syndrome (TLS): Pre-treatment hydration and monitoring are mandatory.
- Concomitant use of strong CYP3A inhibitors during the initiation phase.
- Live vaccines during treatment.
- Pregnancy and breastfeeding.
- Severe renal impairment (requires dose adjustment).
Regular blood tests are required during therapy. Potential side effects:
- 🩸 Hematologic: Neutropenia (low white blood cells), anemia, thrombocytopenia.
- ⚠️ Tumor Lysis Syndrome (TLS): Rapid breakdown of cancer cells affecting kidneys (critical risk during initiation).
- 📉 Diarrhea, nausea, fatigue.
- 🦠 Upper respiratory tract infections.
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