Ventoxen 100 — Venetoclax 100 mg Tablets

Prescribed by hematologists/oncologists for:

• 🔹 Chronic Lymphocytic Leukemia (CLL): Either as monotherapy or in combination with Rituximab/Obinutuzumab.
• 🔹 Acute Myeloid Leukemia (AML): In newly diagnosed adults who are ineligible for intensive chemotherapy (combined with azacitidine or decitabine).
• 🔹 Small Lymphocytic Lymphoma (SLL).

Sales Unit: 1 Bottle (60 Tablets of 100 mg).

⚠️ STRICT DOSING SCHEDULE REQUIRED:

• Ramp-Up Phase: Therapy must NEVER start at 100 mg or 400 mg immediately! The dose is gradually increased over 5 weeks (starting at 20 mg) to prevent fatal Tumor Lysis Syndrome (TLS).
• Maintenance Dose: Typically 400 mg (four 100 mg tablets) once daily.
• Administration: Swallow tablets whole with a meal and water. Do not chew or crush.
• Missed Dose: If within 8 hours, take immediately. If more than 8 hours, skip and resume the next day.

• ⛔ Tumor Lysis Syndrome (TLS): Pre-treatment hydration and monitoring are mandatory.
• Concomitant use of strong CYP3A inhibitors during the initiation phase.
• Live vaccines during treatment.
• Pregnancy and breastfeeding.
• Severe renal impairment (requires dose adjustment).

Regular blood tests are required during therapy. Potential side effects:

• 🩸 Hematologic: Neutropenia (low white blood cells), anemia, thrombocytopenia.
• ⚠️ Tumor Lysis Syndrome (TLS): Rapid breakdown of cancer cells affecting kidneys (critical risk during initiation).
• 📉 Diarrhea, nausea, fatigue.
• 🦠 Upper respiratory tract infections.