Xbira (Abiraterone Acetate) 250 mg
Xbira is a premium-quality generic medication for prostate cancer treatment. Active ingredient: Abiraterone Acetate (250 mg).
Manufacturer: Cipla (India), a global pharmaceutical giant known for high manufacturing standards. Xbira is bioequivalent to Zytiga and works by inhibiting CYP17, an enzyme crucial for androgen production.
Key Features:
- ✅ Trusted Brand: Cipla products are recognized worldwide for their purity and efficacy.
- ✅ Mechanism: Starves the tumor by blocking testosterone production in the testes, adrenal glands, and the tumor itself.
- ✅ Requires co-administration with prednisone/prednisolone.
Indicated for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in adult men.
Usage scenarios:
- Chemo-naive patients: Men with asymptomatic or mildly symptomatic disease after failure of androgen deprivation therapy.
- Post-chemo patients: Men whose disease has progressed on or after a docetaxel-containing chemotherapy regimen.
Standard Dosage: 4 tablets (1,000 mg total) taken orally once daily.
⚠️ CRITICAL ADMINISTRATION WARNING:
- 🚫 MUST be taken on an empty stomach.
- No food for at least 2 hours before the dose and 1 hour after the dose.
- Taking Xbira with food causes a dangerous spike in drug absorption (up to 10-fold increase), risking liver toxicity.
Combination: Always take with low-dose prednisone (usually 5 mg twice daily) to prevent mineralocorticoid excess side effects.
- Women who are or may become pregnant (Category X).
- Severe liver impairment (Child-Pugh Class C).
- Hypersensitivity to abiraterone acetate.
Handling precaution: Pregnant women should not handle Xbira tablets without protection (gloves).
Side effects are manageable with prednisone co-administration. Monitor for:
- Fluid retention (peripheral edema).
- Hypokalemia (low potassium levels).
- Hypertension (high blood pressure).
- Elevated liver enzymes (ALT/AST).
Regular blood tests are required to monitor liver function and potassium levels.
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