Brigatinib: medication list, price and full guide
Brigatinib is a next-generation tyrosine kinase inhibitor (TKI) specifically engineered to target Anaplastic Lymphoma Kinase (ALK) mutations. The drug works by blocking specific proteins that drive the uncontrolled proliferation of cancer cells.
A key feature of this substance is its ability to penetrate the blood-brain barrier, making it highly effective against active brain metastases. On this page of the Unifarm website, you will find a comprehensive list of medications containing Brigatinib available for order.
Indications
- Monotherapy for adult patients with ALK-positive advanced non-small cell lung cancer (NSCLC).
- First-line treatment for patients who have not previously received ALK inhibitors.
- Treatment of patients whose disease has progressed on Crizotinib or who are intolerant to Crizotinib therapy.
Dosage and administration
The medication is taken orally once daily, with water, with or without food. Tablets must be swallowed whole and not crushed or chewed.
Dose Titration Schedule:
- First 7 days: The starting dose is 90 mg once daily.
- Subsequent period: If the starting dose is well tolerated, the dosage is increased to 180 mg once daily.
In case of severe adverse reactions, the physician may interrupt treatment or reduce the dosage.
- Hypersensitivity to the active substance or excipients.
- Pregnancy (can cause fetal harm) and breastfeeding period.
- Pediatric use under 18 years of age (safety and efficacy have not been established).
- Severe hepatic or renal impairment (requires caution and monitoring).
Therapy requires medical supervision due to the risk of the following reactions:
- Respiratory system: Interstitial lung disease (pneumonitis), cough, dyspnea.
- Cardiovascular system: Hypertension (high blood pressure), bradycardia (slow heart rate).
- Laboratory values: Elevated CPK (creatine phosphokinase), hyperglycemia, increased amylase/lipase.
- Senses: Visual disturbances (blurred vision, diplopia).
- Gastrointestinal tract: Nausea, diarrhea, vomiting.
