Ibrutinix Capsules — Ibrutinib 140 mg (120 Caps) Everest

Prescribed by hematologists/oncologists for adult patients with:

• 🔹 Chronic Lymphocytic Leukemia (CLL) / Small Lymphocytic Lymphoma (SLL): Both first-line and relapsed/refractory cases.
• 🔹 Mantle Cell Lymphoma (MCL): For patients who have received at least one prior therapy.
• 🔹 Waldenström's Macroglobulinemia (WM).
• 🔹 Chronic Graft-Versus-Host Disease (cGVHD): After failure of systemic therapy.

Sales Unit: Bottle containing 120 capsules (140 mg strength).

⚠️ APPLICATION INSTRUCTIONS:

• Dosage: Typically 420 mg (3 capsules) for CLL/WM or 560 mg (4 capsules) for MCL, taken once daily. Follow your doctor's exact prescription.
• Administration: Swallow capsules whole with a glass of water. Do not open, break, or chew. Take at the same time each day.
• Dietary Warning: Avoid grapefruit and Seville oranges, as they can dangerously increase the drug level in your blood.
• ✋ Surgery: Must be stopped 3-7 days before any surgery or dental procedure due to bleeding risk.

• ⛔ Pregnancy & Breastfeeding: Strictly contraindicated.
• Hypersensitivity to Ibrutinib.
• Severe hepatic (liver) impairment.
• Children (under 18 years).
• Concomitant use with strong CYP3A inhibitors or preparations containing St. John's Wort.

Monitoring for bleeding and heart rhythm is essential. Potential side effects:

• 🩸 Hemorrhage: Bruising, nosebleeds, or prolonged bleeding from minor cuts.
• ❤️ Cardiac: Atrial fibrillation or flutter (irregular heartbeat).
• 🦠 Infections: Increased risk of upper respiratory tract infections.
• 🤢 Digestive: Diarrhea (very common), nausea. Hydration is key.