Pazorest Tablets — Pazopanib 200 mg (28 Tabs) Everest

Prescribed by oncologists for adults with:

• 🔹 Advanced Renal Cell Carcinoma (RCC): For patients with advanced kidney cancer (first-line treatment or after cytokine therapy).
• 🔹 Advanced Soft Tissue Sarcoma (STS): For patients who have received prior chemotherapy (excluding adipocytic sarcoma and GIST).

Sales Unit: Bottle containing 28 film-coated tablets (200 mg strength).

⚠️ APPLICATION INSTRUCTIONS:

• How to Take: Take on an empty stomach (at least 1 hour before or 2 hours after a meal). Food significantly increases absorption, which can lead to toxicity.
• Method: Swallow tablets whole with water. Do not crush or chew.
• Standard Dose: Typically 800 mg (four 200 mg tablets) once daily. Follow your doctor's instructions for dose reduction if needed.
• ✋ Missed Dose: Do not take if less than 12 hours remain until the next scheduled dose.

• ⛔ Pregnancy & Breastfeeding: Contraindicated. Can cause fetal harm. Effective contraception is mandatory.
• Severe hepatic (liver) or renal (kidney) impairment.
• Children (under 18 years).
• Hypersensitivity to Pazopanib.
• Avoid grapefruit and grapefruit juice during treatment.

Regular monitoring of blood pressure and liver function is required. Potential side effects:

• 📉 Cardiovascular: Hypertension (high blood pressure).
• 🤢 Gastrointestinal: Diarrhea, nausea, vomiting, loss of appetite.
• 💅 Physical: Hair color changes (depigmentation/whitening), skin rash.
• 🩸 Liver: Elevated liver enzymes (hepatotoxicity).
• 🥱 General: Fatigue and weakness.