Renaxen 1 Tablets — Axitinib 1 mg (120 Tabs) Everest

Prescribed by oncologists for the treatment of adult patients with:

• 🔹 Advanced Renal Cell Carcinoma (RCC): Specifically indicated after failure of one prior systemic therapy (e.g., sunitinib or cytokine-based regimens).

Sales Unit: Box containing 120 tablets (1 mg strength).

⚠️ APPLICATION INSTRUCTIONS:

• Standard Starting Dose: Typically 5 mg taken orally twice daily. Note: Since these are 1 mg tablets, multiple tablets may be required to reach the prescribed dose. Always follow your oncologist's count.
• Use of 1 mg: Often prescribed when a patient needs to reduce the dose (e.g., to 3 mg or 2 mg BID) due to side effects.
• Administration: Take doses approximately 12 hours apart. Can be taken with or without food. Swallow whole with a full glass of water.
• ✋ Missed Dose: If a dose is missed or vomiting occurs, do not take an extra dose. Resume the regular schedule at the next time.

• ⛔ Pregnancy & Breastfeeding: Strictly contraindicated. Can cause fetal harm.
• Hypersensitivity to Axitinib.
• Severe hepatic impairment (Child-Pugh Class C).
• History of arterial thromboembolic events (stroke, heart attack) within the last 12 months.
• Uncontrolled hypertension.

Blood pressure and thyroid function must be monitored regularly. Potential side effects include:

• 📈 Hypertension: High blood pressure (very common).
• 🤢 Gastrointestinal: Diarrhea, nausea, vomiting, decreased appetite.
• 🗣️ Dysphonia: Hoarseness or voice changes.
• 🦋 Thyroid: Hypothyroidism (low thyroid hormone levels).
• ✋ Skin: Hand-Foot Syndrome (Palmar-plantar erythrodysesthesia).