Renaxen 5 Tablets — Axitinib 5 mg (60 Tabs) Everest

Prescribed by oncologists for the treatment of adult patients with:

• 🔹 Advanced Renal Cell Carcinoma (RCC): Specifically indicated after failure of one prior systemic therapy (e.g., sunitinib or cytokine-based regimens).

Sales Unit: Box containing 60 film-coated tablets (5 mg strength). This provides exactly a 30-day supply.

⚠️ APPLICATION INSTRUCTIONS:

• Standard Dosage: 5 mg (one tablet) taken orally twice daily.
• Administration: Take doses approximately 12 hours apart. Can be taken with or without food. Swallow whole with a full glass of water. Do not crush or chew.
• ✋ Missed Dose: If a dose is missed or vomiting occurs, do not take an extra dose. Resume the regular schedule at the next time.
• Adjustment: Dosage may be titrated by the physician based on individual safety and tolerability.

• ⛔ Pregnancy & Breastfeeding: Strictly contraindicated. Can cause fetal harm.
• Hypersensitivity to Axitinib.
• Severe hepatic impairment (Child-Pugh Class C).
• History of arterial thromboembolic events (stroke, heart attack) within the last 12 months.
• Uncontrolled hypertension.

Blood pressure and thyroid function must be monitored regularly. Potential side effects include:

• 📈 Hypertension: High blood pressure (very common).
• 🤢 Gastrointestinal: Diarrhea, nausea, vomiting, decreased appetite.
• 🗣️ Dysphonia: Hoarseness or voice changes.
• 🦋 Thyroid: Hypothyroidism (low thyroid hormone levels).
• ✋ Skin: Hand-Foot Syndrome (Palmar-plantar erythrodysesthesia).