Approved for the treatment of adult patients with: 🎗️ Metastatic Colorectal Cancer (mCRC): Who have been previously treated with standard chemotherapy (fluoropyrimidine, oxaliplatin, irinotecan). 🎗️ Metastatic Gastric Cancer: Including adenocarcinoma of the gastroesophageal junction, after at least two prior lines of chemotherapy.

Dosage and administration

Packaging: Bottle of 20 Tablets (20 mg / 8.19 mg). ⚠️ DOSING SCHEDULE (28-Day Cycle): 🧮 Calculation: The dose is strictly calculated based on Body Surface Area (BSA). 📅 Regimen: Typically taken twice daily on Days 1 through 5 and Days 8 through 12 of each 28-day cycle. 🍽️ With Food: Must be taken within 1 hour after completion of morning and evening meals. Taking it on an empty stomach reduces effectiveness. Swallow whole with water.

Severe renal or hepatic impairment. Pregnancy and breastfeeding (embryo-fetal toxicity). Hypersensitivity to Trifluridine or Tipiracil.

Monitoring is crucial due to bone marrow suppression: 📉 Myelosuppression: Severe neutropenia (risk of sepsis), anemia, and thrombocytopenia. Complete blood counts (CBC) must be monitored prior to and during the cycle. 🤢 Gastrointestinal: Nausea, vomiting, decreased appetite, diarrhea. 😴 Fatigue: Asthenia and extreme tiredness are very common.

Tipanat — Trifluridine 20 mg / 8.19 mg, 20 pcs, Natco

100% original product

Active ingredient

Trifluridine Tipiracil

Manufacturer

Natco

Dosage 20 mg / 8.19 mg

Dosage form Tablets

Tablets per pack 20

Tipanat (Trifluridine / Tipiracil) 20 mg

Name: Tipanat
Brand: Natco
SKU: PROD-103
Price: 8614 UAH
Availability: InStock

8614₴ ~~9229₴~~ -7%

Tipanat 20 (Trifluridine / Tipiracil) is a combination oral chemotherapy drug.

Manufacturer: Natco Pharma (India). Tipanat is a cost-effective generic version of the brand-name drug Lonsurf.

Mechanism of Action ("The Attacker and The Protector"):

It consists of two active ingredients. Trifluridine is the "attacker": it incorporates directly into the cancer cell's DNA, preventing it from multiplying. Tipiracil acts as the "protector": it inhibits the enzyme that usually breaks down Trifluridine in the body, maintaining high enough levels of the drug in the blood to effectively fight the tumor.

✅ Key Benefit: Offers a survival advantage for patients with metastatic gastrointestinal cancers refractory to other treatments.

Approved for the treatment of adult patients with:

🎗️ Metastatic Colorectal Cancer (mCRC): Who have been previously treated with standard chemotherapy (fluoropyrimidine, oxaliplatin, irinotecan).
🎗️ Metastatic Gastric Cancer: Including adenocarcinoma of the gastroesophageal junction, after at least two prior lines of chemotherapy.

Packaging: Bottle of 20 Tablets (20 mg / 8.19 mg).

⚠️ DOSING SCHEDULE (28-Day Cycle):

🧮 Calculation: The dose is strictly calculated based on Body Surface Area (BSA).
📅 Regimen: Typically taken twice daily on Days 1 through 5 and Days 8 through 12 of each 28-day cycle.
🍽️ With Food: Must be taken within 1 hour after completion of morning and evening meals. Taking it on an empty stomach reduces effectiveness. Swallow whole with water.

Severe renal or hepatic impairment.
Pregnancy and breastfeeding (embryo-fetal toxicity).
Hypersensitivity to Trifluridine or Tipiracil.

Monitoring is crucial due to bone marrow suppression:

📉 Myelosuppression: Severe neutropenia (risk of sepsis), anemia, and thrombocytopenia. Complete blood counts (CBC) must be monitored prior to and during the cycle.
🤢 Gastrointestinal: Nausea, vomiting, decreased appetite, diarrhea.
😴 Fatigue: Asthenia and extreme tiredness are very common.

Notice. The information on this page is for reference only and does not replace medical consultation. Always consult a healthcare professional and read the manufacturer's instructions before using any medicine. Self-medication may be dangerous. Information updated: 23.03.2026

Active ingredient

Trifluridine Tipiracil

Manufacturer

Natco

Dosage 20 mg / 8.19 mg

Dosage form Tablets

Tablets per pack 20

100% original product

Delivery across Ukraine

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