Trifluxen — Trifluridine and Tipiracil 15 mg + 6.14 mg Tablets

Prescribed by oncologists for patients with disease progression following prior therapies:

• 🔹 Metastatic Colorectal Cancer (mCRC): For patients previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy.
• 🔹 Metastatic Gastric Cancer or Gastroesophageal Junction Adenocarcinoma.

Sales Unit: 1 Bottle (30 Tablets, 15 mg / 6.14 mg).

⚠️ COMPLEX DOSING SCHEDULE (Cycles):

• Dose Calculation: The exact number of tablets is determined by the doctor based on the patient's Body Surface Area (BSA).
• Cycle Schedule (28 days): Typically taken for 5 days, followed by 2 days rest, then 5 days taken, followed by 14 days rest.
• Frequency: Taken twice daily (morning and evening).
• 🍽️ Administration: Must be taken within 1 hour AFTER completion of a meal with water. Do not take on an empty stomach.
• Safety: Wash hands after handling. Pregnant women should not handle the tablets.

• ⛔ Severe Renal or Hepatic Impairment: Requires strict monitoring and potential dose adjustment.
• Pregnancy and breastfeeding (harmful to the fetus).
• Children (under 18 years of age).
• Hypersensitivity to active substances.

Regular Complete Blood Counts (CBC) are mandatory during therapy. Potential side effects:

• 🩸 Bone Marrow Suppression: Neutropenia (infection risk), anemia (fatigue), thrombocytopenia (bleeding risk).
• 📉 Gastrointestinal: Nausea, vomiting, diarrhea, loss of appetite.
• 🔋 General: Severe fatigue, weakness.
• Seek immediate medical attention if fever or signs of infection occur!