Sofokast + Dacikast (Sofosbuvir + Daclatasvir) Kit
Sofokast + Dacikast Kit is a comprehensive dual-drug regimen for the curative treatment of Chronic Hepatitis C.
Manufacturer: Aprazer (India). Note: Sofokast is manufactured under a license from Gilead Sciences, ensuring bioequivalence to the original Sovaldi. This is a "Pan-Genotypic" regimen, meaning it is effective against all major strains of the virus.
Mechanism of Action ("Dual Inhibition"):
The kit combines two Direct-Acting Antivirals (DAAs):
- 🛡️ Sofosbuvir 400 mg: An NS5B polymerase inhibitor (stops replication).
- ⚔️ Daclatasvir 60 mg: An NS5A inhibitor (stops viral assembly).
✅ Result: Achieves Sustained Virologic Response (cure) in over 95-98% of patients after a standard 12-week course.
Indicated for the treatment of chronic hepatitis C virus (HCV) infection in adults:
- 🦠 Genotypes 1-6: Universal coverage.
- 🏥 Liver Status: Safe for patients with compensated cirrhosis or without cirrhosis.
- 🔄 Treatment-Experienced: Effective for patients who failed prior interferon-based therapy.
Packaging: Two separate bottles (28 tablets each). This represents a 4-week supply.
⚠️ ADMINISTRATION PROTOCOL:
- 💊 Daily Dose: Take ONE tablet of Sofosbuvir and ONE tablet of Daclatasvir together once daily.
- ⏰ Consistency: Take at the same time every day to prevent viral mutation.
- 🍽️ Food: Can be taken with or without food. Swallow whole, do not crush.
- 📅 Duration: Standard course is 12 weeks (3 kits). Extended to 24 weeks for decompensated cirrhosis (under medical supervision).
- Pregnancy and breastfeeding (Strictly contraindicated).
- Co-administration with Amiodarone (Risk of severe bradycardia/heart arrest).
- Use with strong P-gp inducers (e.g., Rifampin, St. John’s Wort) as they reduce drug efficacy.
Generally well-tolerated with mild side effects:
- 🤕 Common: Headache, fatigue/tiredness.
- 🤢 Gastrointestinal: Mild nausea.
- Rarely: Insomnia or dizziness.
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