Enzalutamide – Targeted Therapy

Enzalutamide is a potent second-generation selective androgen receptor signaling inhibitor. The drug is specifically designed to treat advanced prostate cancer and acts at several stages of the signaling pathway that stimulates tumor cell growth under the influence of male sex hormones.

The mechanism of action of enzalutamide is multi-step. Unlike earlier antiandrogens, it not only competitively inhibits the binding of androgens to receptors but also prevents the translocation of the activated receptor into the cell nucleus and blocks its interaction with DNA. This effectively halts the transcription of genes responsible for cancer cell division and survival. As a result, tumor growth slows down, and levels of prostate-specific antigen (PSA) in the blood decrease.

The drug is intended for oral administration and possesses high bioavailability. Enzalutamide significantly extends the time to disease progression and increases overall survival in patients both before and after receiving chemotherapy.

Wikipedia page
Enzalutamide

Indications

Enzalutamide is used in urologic oncology for the therapy of progressive forms of prostate cancer:

  • Metastatic Castration-Resistant Prostate Cancer (mCRPC): treatment of adult men when hormonal therapy has failed.
  • Non-metastatic Castration-Resistant Prostate Cancer (nmCRPC): therapy for patients at high risk of developing metastases.
  • Metastatic Hormone-Sensitive Prostate Cancer (mHSPC): use in combination with androgen deprivation therapy.
  • Therapy Resistance: the drug is effective in patients previously treated with docetaxel and in those for whom chemotherapy has not yet been prescribed.

Dosage and administration

The enzalutamide dosing regimen requires regularity and adherence to the established dosage.

  • Standard Dose: 160 mg (four 40 mg capsules or tablets) once daily.
  • Administration Rules: the drug is taken orally as a whole, with or without food. It is important to take the dose at the same time every day.
  • Missed Dose: if a dose is missed, it should be taken as soon as possible on the same day. If the next day has arrived, the missed dose should not be taken.
  • Drug Interactions: enzalutamide is a strong inducer of CYP3A4 enzymes, which can reduce the efficacy of many concomitantly administered medications.
  • Duration of Treatment: therapy continues as long as a clinical benefit is maintained or until signs of unacceptable toxicity appear.

The use of enzalutamide is contraindicated in the following cases:

  • Hypersensitivity: known allergy to enzalutamide or any excipients in the medication.
  • Women and Children: the drug is strictly contraindicated in women (especially those who are pregnant) and children. Contact by pregnant women with the drug is unacceptable due to the risk to the fetus.
  • Severe Renal Impairment: safety in patients with end-stage renal disease has not been established.
  • Severe Hepatic Impairment: (Child-Pugh Class C).
  • Seizure Risk: use with caution in individuals with a predisposition to seizures or a history of brain injury.

Enzalutamide therapy may cause a range of side effects requiring medical attention:

  • General Symptoms: severe asthenia (weakness), increased fatigue, and hot flashes.
  • Nervous System: headache, risk of seizures (rare), and impaired concentration.
  • Musculoskeletal System: back pain, joint pain (arthralgia), and an increased risk of bone fractures.
  • Cardiovascular System: increased blood pressure (hypertension).
  • Digestive System: decreased appetite, nausea, and changes in taste perception.

Frequently Asked Questions

Enzalutamide is a potent androgen receptor inhibitor. It is used to treat various forms of prostate cancer, including castration-resistant prostate cancer (CRPC). The drug works by blocking the effects of testosterone on cancer cells, thereby slowing down tumor growth and spread.
Xtandi is the original drug by Astellas. Indian generics (e.g., from BDR or Glenmark) contain the same active ingredient in 40mg or 80mg dosages. The main difference is the significantly lower price on Unifarm while maintaining strict manufacturing quality standards.
The standard daily dose is 160 mg (typically four 40 mg capsules), taken once daily at the same time. The capsules should be swallowed whole, with or without food. Any dose adjustments must be made by your physician.
The most frequent side effects include fatigue, hot flashes, headache, and hypertension. A rare but serious risk is seizures; therefore, it is crucial to inform your doctor of any pre-existing neurological conditions.
The price of Indian enzalutamide generics on our website is several times lower than the original's cost in retail pharmacies. We work directly with verified suppliers. Current pricing is listed on the product page and depends on the chosen manufacturer.
Enzalutamide can interact with many drugs, including anticoagulants and cardiovascular medications. Before starting treatment, be sure to provide your doctor with a complete list of all medications you are currently taking.
Select the desired medication from the catalog, add it to your cart, and enter your delivery details. We provide fast shipping across Ukraine. If you have questions about choosing a generic, our managers are always ready to assist via phone or messaging apps.

List of medicines by active substance Enzalutamide

-10%
Hetenza 40 mg Heet Healthcare
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Heet Healthcare

Hetenza

Enzalutamide
40 mg 112 capsules
7911₴ 8790₴
-8%
Xtandi 40 mg Astellas
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Astellas

Xtandi

Enzalutamide
40 mg 112 capsules
36478₴ 39554₴
-7%
Enzamide 40 mg Everest
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Everest

Enzamide

Enzalutamide
40 mg 30 tablets
10987₴ 11866₴
-12%
Indenza 40 mg Aprazer
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Aprazer

Indenza

Enzalutamide
40 mg 112 capsules
8526₴ 9669₴
-12%
Bdenza 40 mg BDR
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BDR

Bdenza

Enzalutamide
40 mg 112 capsules
8526₴ 9669₴
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