Treatment of HIV-1 infection in adults and adolescents (aged 12+ and weighing at least 40 kg). Must be used in combination with other antiretroviral agents (ART regimen). Suitable for: Treatment-naive patients (starting therapy for the first time). Treatment-experienced patients (switching due to side effects or resistance).

Dosage and administration

Standard Dosage: One tablet (50 mg) once daily. ⚠️ CRITICAL INTERACTION WARNING (Antacids & Vitamins): Dolutegravir binds to cations (Aluminum, Magnesium, Calcium, Iron). If you take multivitamins, antacids, or laxatives: 💊 Take Instgra at least 2 hours BEFORE or 6 hours AFTER these supplements. Failure to separate doses will drastically reduce drug absorption. May be taken with or without food.

Hypersensitivity to Dolutegravir. Co-administration with Dofetilide: Strictly prohibited due to potential life-threatening toxicity. Note on Resistance: Patients with known resistance to Integrase Inhibitors may require a double dose (50 mg twice daily) — consult your doctor.

Generally well-tolerated. Potential side effects include: Insomnia: Difficulty sleeping (try taking the dose in the morning). Headache. Weight gain (a known effect of modern INSTI-based regimens). Fatigue.

Instgra — Dolutegravir 50 mg, 30 pcs, Emcure

100% original product

Active ingredient

Dolutegravir

Manufacturer

Emcure

Dosage 50 mg

Dosage form Tablets

Tablets per pack 30

Instgra — Dolutegravir 50 mg

Name: Instgra
Brand: Emcure
SKU: PROD-18
Price: 3516 UAH
Availability: InStock

3516₴ ~~3955₴~~ -11%

Instgra is a highly effective antiretroviral medication for HIV treatment. Active ingredient: Dolutegravir (50 mg).

Manufacturer: Emcure Pharmaceuticals (India). Generic equivalent of Tivicay. It belongs to the class of Integrase Strand Transfer Inhibitors (INSTIs).

Why it is a preferred choice:

Instgra prevents the HIV virus from integrating its genetic material into human cells. It is recommended by the WHO as a first-line treatment due to its high barrier to genetic resistance and rapid viral suppression.

✅ Benefits: Once-daily dosing, small tablet size, no need for pharmacokinetic boosting (Ritonavir).

Treatment of HIV-1 infection in adults and adolescents (aged 12+ and weighing at least 40 kg).

Must be used in combination with other antiretroviral agents (ART regimen).

Suitable for:

Treatment-naive patients (starting therapy for the first time).
Treatment-experienced patients (switching due to side effects or resistance).

Standard Dosage: One tablet (50 mg) once daily.

⚠️ CRITICAL INTERACTION WARNING (Antacids & Vitamins):

Dolutegravir binds to cations (Aluminum, Magnesium, Calcium, Iron). If you take multivitamins, antacids, or laxatives:

💊 Take Instgra at least 2 hours BEFORE or 6 hours AFTER these supplements.
Failure to separate doses will drastically reduce drug absorption.

May be taken with or without food.

Hypersensitivity to Dolutegravir.
Co-administration with Dofetilide: Strictly prohibited due to potential life-threatening toxicity.

Note on Resistance: Patients with known resistance to Integrase Inhibitors may require a double dose (50 mg twice daily) — consult your doctor.

Generally well-tolerated. Potential side effects include:

Insomnia: Difficulty sleeping (try taking the dose in the morning).
Headache.
Weight gain (a known effect of modern INSTI-based regimens).
Fatigue.

Notice. The information on this page is for reference only and does not replace medical consultation. Always consult a healthcare professional and read the manufacturer's instructions before using any medicine. Self-medication may be dangerous. Information updated: 10.03.2026