Tenomtra Tablets — Tenofovir Alafenamide, Emtricitabine, Dolutegravir
Tenomtra is an innovative combined medication for HIV treatment, representing a complete single-tablet regimen. It consists of three modern components: Dolutegravir (50 mg), Emtricitabine (200 mg), and Tenofovir Alafenamide (25 mg). A key feature of the drug is the use of Tenofovir Alafenamide (TAF) — a more advanced form of tenofovir that provides less strain on the kidneys and bone system while maintaining high efficacy.
Manufacturer: Leowin Pharmaceuticals. Tenomtra ensures maximum viral load suppression and a high genetic barrier to the development of resistance. The "one pill a day" regimen significantly improves treatment adherence and the patient's quality of life.
Key Features:
- ✅ Modern Standard: This combination is recommended by leading international protocols (IAS, EACS) as one of the most effective and safe options.
- ✅ Organ Safety: Due to the TAF form, the drug has minimal impact on bone mineral density and kidney function.
- ✅ Fast Results: The inclusion of Dolutegravir allows for reducing the viral load to an undetectable level in the shortest possible time.
Tenomtra is prescribed by HIV specialists for adults and adolescents (weighing more than 40 kg):
- 🔹 Treatment of HIV-1 infection in antiretroviral therapy (ART) naive patients.
- 🔹 Replacement of the current ART regimen in patients with a suppressed viral load and no history of treatment failure with integrase inhibitors.
Sales Form: 1 bottle contains 30 tablets (a 30-day course).
⚠️ INSTRUCTIONS FOR USE:
- Dosage Regimen: The recommended dose is 1 tablet once daily.
- Method of Administration: The tablet is taken orally, swallowed whole. It can be taken regardless of food. It is recommended to take the drug at the same time every day.
- Missed Dose: If the dose is missed by more than 12 hours, wait for the next scheduled dose. If missed by less than 12 hours, take the tablet immediately.
- Storage: Store in a dry place at temperatures up to 30°C, in the tightly closed original bottle.
- ⛔ Drug Interaction: Co-administration with dofetilide (anti-arrhythmic drug) is strictly prohibited.
- ⛔ Renal Impairment: Not recommended for patients with severe renal failure (creatinine clearance below 30 mL/min).
- ⛔ Hypersensitivity: Allergy to any of the three components (dolutegravir, emtricitabine, tenofovir alafenamide).
- ⛔ Pregnancy: Use is only possible after consultation with a doctor and evaluation of all risks.
Tenomtra is usually well-tolerated. Possible side effects:
- 🧠 Nervous System: Headache, insomnia, dizziness, unusual dreams.
- 🤢 GI Tract: Nausea, diarrhea, slight abdominal discomfort.
- 🧪 Metabolism: Possible risk of some weight gain (typical for combinations with dolutegravir and TAF).
- 🏃♂️ General: Fatigue, skin rash.
- 🩸 Liver: In patients with Hepatitis B co-infection, serious exacerbations may occur upon discontinuation (requires medical monitoring).
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